2009.04-至今，任职于湖北省农业科学院生物农药工程研究中心；

2005.09-2009.03，博士毕业于华东理工大学药学院，应用化学专业，获工学博士学位；期间于2008.02-2008.08在大连理工大学环境与生命学院从事分子生物学试验研究；

2002.09-2005.07，硕士毕业于上海师范大学生命与环境科学学院，获理学硕士学位；

1998.09-2002.07，本科毕业于华中师范大学化学学院，获理学学士学位。

美国化学学会会员（2015），亚洲科学编辑委员会会员（2018）、BENTHAM AMBASSADOR（2018）、国际期刊Chemical Biology Letters及Academia Journal of Agricultural Research编委，中国科技论文在线特聘专家（2013）；美国化学会、英国皇家化学会、欧洲药学会、中国化学会及Elsevier、SpringLink、Bentham、Taylor and Francis等国际出版社主办的二十余种SCI源刊论文评审专家，波兰基金项目通讯评审专家。

微生物资源导向的农药及药物的先导发现及化学生物学

1、   农业生物药物分子靶标发现与绿色药物分子设计（2017YFD0200502），国家“化学肥料和农药减施增效综合技术研发”重点专项，2017.7-2020.12；

2、   杂环亚胺作为新型杀虫剂的先导优化及应用研究（2016020101010093），武汉市应用基础研究计划项目，2016.8-2018.8；

3、   PI3K/Akt信号通路在DHEA衍生物抗EV71中的作用研究（31400153），国家自然科学基金，2015.1-2017.12；

4、   亚胺型类烟碱杀虫剂的作用机制及毒理学（2015ZTSJJ9），农业部华中作物有害生物综合治理重点实验室开放基金，2015.8-2017.7；

5、   微生物源农药先导化合物的研究，国家科技支撑计划（2011BAE06B004-02），2011-2015。

1、   柯少勇等. 具有杀虫活性的肟醚或酯衍生物及其制备方法与应用. 授权专利: ZL201010518800.4, 2014.

2、   柯少勇等. 含氮杂环亚胺衍生物及其制备方法和用途. 授权专利: ZL201210171077.6, 2015.

3、   柯少勇等. 共轭双烯衍生物及其制备方法与作为抗癌药物的用途. 授权专利: ZL201310350441.X, 2016.

4、   柯少勇等. 具有双腙结构的甾体衍生物作为抗病毒药物的应用. 授权专利: ZL201410053947.9, 2017.

5、   Ke SY, et al. Conjugated diene derivatives, preparation method therefor, and uses thereof as anticancer drug. PCT Intl. Appl. WO2015021833A1, 2015.

6、   Ke SY, et al. Nitrogenous Heterocyclic Imide Derivative and Preparation Method and Use Thereof. PCT Intl. Appl. WO2013177985A1, 2013.

1.          Ke SY, Shi LQ, Zhang ZG, Yang ZW, Steroidal[17,16-d]pyrimidines derived from dehydroepiandrosterone: A convenient synthesis, antiproliferation activity, structure-activity relationships, and role of heterocyclic moiety, Sci. Rep., 2017, 7, 44439.

2.          Yang QY, Mao Q, Liu ML, Wang KM, Wu ZY, Fang W, Yang ZW, Luo PC, Ke SY*, Shi LQ*, The inhibitory effect of dehydroepiandrosterone and its derivatives against influenza A virus in vitro and in vivo, Arch. Virol., 2016, 161, 3061-3072.

3.          Yu XF, Shi LQ, Ke SY*, Acylhydrazone derivatives as potential anticancer agents: Synthesis, bio-evaluation and mechanism of action, Bioorg. Med. Chem. Lett., 2015, 25, 5772-5776.

4.          Ke SY, Shi LQ, Yang ZW, Discovery of novel isatin-dehydroepiandrosterone conjugates as potential anticancer agents, Bioorg. Med. Chem. Lett., 2015, 25, 4628-4631.

5.          Wei YH, Shi LQ, Wang KM, Liu ML, Yang QY, Yang ZW*, Ke SY*, Discovery of gramine derivatives that inhibit the early stage of EV71 replication in vitro, Molecules, 2014, 19, 8949-8964.

6.          Ke SY, Yang ZW, Zhang ZG, Liang Y, Wang KM, Liu ML, Shi LQ, Multisubstituted indole-acrylonitrile hybrids as potential cytotoxic agents, Bioorg. Med. Chem. Lett., 2014, 24, 1907-1911.

7.          Ke SY, Wei YH, Shi LQ, Yang QY, Yang ZW, Synthesis of novel steroid derivatives derived from dehydroisoandrosterone as potential anticancer agents, Anti-Cancer Agents Med. Chem., 2013, 13, 1291-1298.

8.          Ke SY, Wei YH, Yang ZW, Wang KM, Liang Y, Shi LQ, Novel cycloalkylthiophene-imine derivatives bearing benzothiazole scaffold: Synthesis, characterization and antiviral activity evaluation, Bioorg. Med. Chem. Lett., 2013, 23, 5131-5134.

9.          Ke SY, Zhang ZG, Long T, Liang Y, Yang ZW, Novel salicylamide derivatives incorporating neonicotinoid pharmacophore: Design, synthesis, characterization, and biological evaluation, Med. Chem. Res., 2013, 22, 3621-3628.

10.       Ke SY, Shi LQ, Cao XF, Yang QY, Liang Y, Yang ZW, Heterocycle-functional gramine analogues: Solvent and catalyst-free synthesis and their inhibition activities against cell proliferation, Eur. J. Med. Chem., 2012, 54, 248-254.

11.       Li SW, Cao XF, Chen CS, Ke SY*, Novel salicylic acid-oriented thiourea-type receptors as colorimetric chemosensor: Synthesis, characterizations and selective naked-eye recognition properties, Spectrochimica Acta Part A, 2012, 96, 18-23.

12.       Shi LQ, Hu R, Wei YH, Liang Y, Yang ZW, Ke SY*, Anthranilic acid-based diamides derivatives incorporating aryl-isoxazoline pharmacophore as potential anti-cancer agents: Design, synthesis and biological evaluation, Eur. J. Med. Chem., 2012, 54, 549-556.

13.       Ke SY, Cao XF, Liang Y, Wang KM, Yang ZW, Synthesis and biological properties of dihydro-oxadiazine-based heterocyclic derivatives, Mini Rev. Med. Chem., 2011, 11, 642-657.

14.       Ke SY, Zhang YN, Shu WM, Zhang ZG, Shi LQ, Liang Y, Wang KM, Yang ZW, Structural diversity-guided convenient construction of functionalized polysubstituted butenolides and lactam derivatives, C. R. Chim., 2011, 14, 1071-1079.

15.       Cao XF, Chen CS, Lu WC, Ke SY*, Chiral β-arylalkyl-1H-1,2,4-triazoles as demethylase inhibitors: Biological evaluation and its stereoselective interaction with sterol 14α-demethylase from Penicillium digitatum, Pestic. Biochem. Phys., 2011, 99, 189-193.

16.       Ke SY, Qian XH*, Liu FY, Wang N, Fan F, Li Z, Yang Q, Diacylhydrazine derivatives as novel potential chitin biosynthesis inhibitors: Design, synthesis, and structure-activity relationship, Eur. J. Med. Chem., 2009, 44, 2985-2993.

17.       Ke SY, Liu FY, Wang N, Yang Q, Qian XH*, 1,3,4-Oxadiazoline derivatives as novel potential inhibitors targeting chitin biosynthesis: Design, synthesis and biological evaluation, Bioorg. Med. Chem. Lett., 2009, 19, 332-335.

18.       Ke SY, Qian XH*, Liu FY, Wang N, Yang Q, Li Z, Novel 4H-1,3,4-oxadiazin-5(6H)-ones with hydrophobic and long alkyl chains: Design, synthesis, and bioactive diversity on inhibition of monoamine oxidase, chitin biosynthesis and tumor cell, Eur. J. Med. Chem., 2009, 44, 2113-2121.